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Folli-Fuel · 083

Lyophilization: why the powder is freeze-dried

Freeze-drying explained simply, and why it is used for delicate ingredients like those in Folli-Fuel.

Dr Steven Goh · 123 words

Lyophilization: why the powder is freeze-dried
Answer first

Lyophilization, or freeze-drying, removes water from a frozen product under low pressure, leaving a dry powder. It is widely used for proteins and other delicate ingredients because dry forms tend to be more stable. Folli-Fuel's powder is freeze-dried and mixed just before use.

The process

The product is frozen, then water is removed as vapour without passing through liquid. Reviews of freeze-drying describe it as a way to protect sensitive proteins.

Why it matters

Mixing fresh in the centre means the ingredients are reconstituted only when your session starts. This is about stability, not proof of results.

Questions

Is freeze-dried better than liquid?

It is often more stable for delicate ingredients.

Can I see it being mixed?

Yes.

Studies mentioned

These studies looked at ingredients or general approaches. None of them tested our treatments or products, so they are background, not proof.

  1. Emami F et al. (2018). Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals. Pharmaceutics 10(3).Review (pharmaceutical technology). Freeze-drying is one of the main drying methods used to improve the storage stability of therapeutic proteins.PubMed 30126135doi:10.3390/pharmaceutics10030131
  2. Angkawinitwong U et al. (2015). Solid-state protein formulations. Ther Deliv 6(1):59-82.Review (pharmaceutical technology). Proteins and peptides in liquid form often degrade during handling; solid formulations, including freeze-dried products, are used to maintain stability during storage and transport.PubMed 25565441doi:10.4155/tde.14.98
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